Blar i forfatter "Kaur, Gurjit"

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    • Identifying signaling pathway responsible for SRC-3 serine 857 phosphorylation. A study in lung cancer cells 

      Kaur, Gurjit (Master thesis; Mastergradsoppgave, 2014-05-20)
      Signal transduction mediated by protein kinases and phosphatases is complex and highly coordinated. The mitogen activated protein kinases (MAPKs) are key components that transduce extracellular stimuli to biological responses by a three-tier module. The biological functions of steroid receptor coactivator-3 (SRC-3), a coactivator of nuclear hormone receptors and numerous transcription factors, is ...

    • Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription 

      Shrestha, Anup; Bruckmüller, Henrike; Kildalsen, Hanne; Kaur, Gurjit; Gaestel, Matthias; Ljones Wetting, Hilde; Mikkola, Ingvild; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
      Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Serine 857 ...